Source: PRNewswire
Thursday, November 20, 2008
ST. LOUIS, Nov. 20 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL)
announced today the global release of MISSION(R) In VIVO QUALITY and iScale
Oligos(TM) siRNA. MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA are
expected to allow researchers to successfully take the next step in their RNAi
research with the highest purity and quality siRNA required for RNAi research
in animal models. These siRNA are believed to be well suited to target
validation and pre-clinical siRNA testing. Intermediate and large synthesis
scales and a wide variety of modifications are also available.
advertisement
"Increasingly, RNAi researchers are utilizing animal models to confirm
findings from cell culture based assays or to explore the use of siRNA as a
potential therapeutic agent," said Tim Fleming, Director of Global Commercial
Marketing at Sigma-Aldrich. "Our goal is to provide an siRNA that is capable
of facilitating in vivo siRNA research, with the purity levels required for
direct delivery or to be used as an essential part of an overall in vivo
formulation strategy."
MISSION(R) In VIVO QUALITY siRNA are processed specifically for in vivo
usage. This purification process includes RP-HPLC to ensure a high percentage
of full-length product (>94%), dialysis on the annealed product to remove
excess salts, 22 micrometer sterile filtration, and finally testing to ensure
no endotoxins are present.
In addition, iScale Oligos(TM) synthesis scales can give customers the
large quantities of siRNA required for in vivo usage with amounts up to 100mg.
MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA are available with many
of the common modifications used to for tracking or stability, such as FAM,
Cy5(TM), and Cy3(TM).
"Sigma-Aldrich's MISSION(R) In VIVO QUALITY siRNAs are used exclusively at
BIOO Scientific(TM) for all of our internal in vivo formulation development
programs," said Lance Ford, Vice President of Research and Development at BIOO
Scientific(TM) Corporation. "Most recently, we have used these siRNAs to with
great success to demonstrate the utility of our new in vivo formulation,
MaxSuppressor(TM) In Vivo RNA-LANCEr II (catalog #3410-01), in mouse models.
BIOO Scientific(TM) Corporation recommends these siRNAs to our all of our
customers as they are exceptional siRNAs, offered at a competitive price, with
rapid turnaround times and supported by Sigma-Aldrich's professional service."
For more information on the MISSION(R) In VIVO QUALITY and iScale
Oligos(TM) siRNA, please visit http://sigma-aldrich.com/invivosirna.
About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High
Technology company. Our biochemical and organic chemical products and kits are
used in scientific and genomic research, biotechnology, pharmaceutical
development, the diagnosis of disease and as key components in pharmaceutical
and other high technology manufacturing. We have customers in life science
companies, university and government institutions, hospitals, and in industry.
Over one million scientists and technologists use our products. Sigma-Aldrich
operates in 36 countries and has 8,000 employees providing excellent service
worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through
Leadership in Life Science, High Technology and Service. For more information
about Sigma-Aldrich, please visit our award-winning website at
http://www.sigma-aldrich.com.